Urobilinogen in Urine: Low & High Levels + Normal Range
Apr 07, · 1) Liver Disease or Damage. Liver damage and disease (e.g., viral hepatitis and liver cirrhosis) can increase bilirubin levels, resulting in higher urobilinogen levels in the urine [ 1 ]. Urobilinogen levels also correlate with blood levels of liver enzymes (e.g. ALT, AST), which rise in response to liver damage [ 26 ]. Because of certain health conditions, a person excretes a dark-yellow urine, which may indicate the presence of high urobilinogen. In some medical conditions, it can be absent or too low. If you get any of these results, it is best to consult your doctor because it indicates a health problem, specifically in the functioning of your liver.
If you have urobilinogen in your urine, your doctor will likely inform you of it during a routine urinalysis. Urobilinogen is a by-product of bilirubin, which is a yellow compound processed by your liver that occurs in the normal catabolic pathways responsible for breaking down red blood cell products through hemolysis. Urobilinogen is formed in the intestines, and half of it is reabsorbed for normal circulation and excreted through your urine, while what remains is excreted in the stool.
When bilirubin is created, it produces urobilinogen, which can be used as a measure of your liver function. Having a urobilinogen level above or below this range is considered abnormal in a clinical setting. Elevated urobilinogen levels may indicate excess RBC red blood cell breakdown, liver overburdening, hematoma, poisoning, or even liver cirrhosis. Decreased urobilinogen levels may indicate a blockage in the bile duct system or bile production failure.
Caused by a number of different medical, bacterial, and parasite infections. Hemolysis is a process where RBCs are broken down too soon, requiring bone marrow to produce more red blood cells to compensate. When RBCs are broken down, they release their contents, which then get processed by the liver and form bilirubin and urobilinogen.
There is a delicate balance of breakdown and production that could be put in flux during cases of abnormal hemolysis. The vitamins folic acid and How to enlarge a pdf file are necessary to produce RBCs.
If the body is deficient in any of the two substances, it will cause pernicious anemia — a condition where the body does not have enough red blood cells.
Insufficient amounts of B12 can cause the destruction of RBCs what does high urobilinogen mean the bone marrow, indirectly increasing bilirubin production. The liver is the primary organ involved in a vast amount of metabolic processes, including the processing of bilirubin.
When the liver is not performing adequately, a build-up of bilirubin can be appreciated and subsequently a build-up of urobilinogen. These are important clues your doctor will use to investigate further. Various diseases affecting the liver include hepatitis, cirrhosis, and liver cancer. A rare hereditary genetic disorder that leads to an isolated increase in bilirubin. If you were to examine the livers of these individuals, they would appear black due to the deposition of a pigment similar to melanin.
A rare and relatively benign condition that is quite similar to Dubin-Johnson syndrome, as both cause an increase in conjugated bilirubin. A condition that is characterized by the heart not being able to pump as much blood as it needs to ensure how to price a salvage title vehicle perfusion. In response to the hearts decreased ability to pump blood, your kidneys will attempt to compensate by causing the body to retain fluid.
Unfortunately, this will cause the arms, legs, ankles, and other organs to swell up and appear congested. A common occurrence when ingesting lead-based paint or lead-contaminated dust in older buildings. Other sources of lead poisoning include contaminated air, water, and soil. Lead is a poison that can build up in the body over time, leading to health problems and severe liver damage. The blockage of the ducts that transport bile, interrupting proper flow.
This can be caused by gallstones blocking the passageway, making them narrow as a result of scar tissue formation. A rare inherited disorder affecting the metabolism of bilirubin, resulting in high levels of unconjugated bilirubin found in the blood stream. If left untreated in newborns, this condition can lead to irreversible brain damage.
Taking antibiotics can wipe out beneficial bacteria in the gut that help transform bilirubin into urobilinogen. Vitamin C and ammonium chloride can also increase the acidity of the urine when taken in high amounts. Acidic urine will lower the concentration of urobilinogen. Urobilinogen levels can be tested with the use of urobilinogen test dip-sticks. These dip-sticks make use of P-dimethylamino-benzaldehyde, which is known to react strongly to acidic conditions, with urobilinogen producing a pink color upon contact.
However, the test strip may appear obscured in color owing to the presence of p-aminosalicylic acid and sulphonamides in high concentrations. The urobilinogen strip test should be considered a diagnostic tool. Your doctor will outline the best treatment options available depending on the cause of your abnormal levels of urobilinogen, with the goal to eliminate the how to repair cast iron tub as soon as possible.
If your case of urobilinogen is due to hemolysis, iron supplementation will be utilized to help replace lost red blood cells. If abnormal urobilinogen is due to medication, you will either be switched to an alternative or be told to stop the medication outright. Cases of liver disease will require more extensive treatment and you will be monitored closely.
In the most severe of cases, a liver transplant may be required. Abnormal urobilinogen levels are not something that most people stress about, as they may not know exactly what its implications are. But the bottom line is that abnormal levels indicate that something going on in your body is not normal. Knowing that your liver and other what does high urobilinogen mean processes contribute to this value, engaging in regular exercise and what are the natural resources of brazil a healthy diet while avoiding liver damaging substances will help.
Related: What causes liver pain? In this article: Urobilinogen in urine ranges What causes urobilinogen in urine? Tests and treatment for urobilinogen in urine.
What Does It Mean When You Have Urobilinogen in Your Urine?
If your test results show too little or no urobilinogen in your urine, it may indicate: A blockage in the structures that carry bile from your liver. A blockage in the blood flow of the liver. A problem with liver function. If your test results show a higher-than-normal level of urobilinogen, it may indicate: Hepatitis. . Feb 09, · A higher level of urobilinogen in urine can be an indication of something more serious, as it means that you may be suffering from a disease that is hindering the normal functioning of your liver. This may be due to cancer of the liver or cirrhosis. In such cases, you will require immediate medical attention. Urobilinogen is processed by the liver, sent to the intestine and leaves. It only appears in the urine if the amount in blood is too high. So although it's detected in urine, the kidneys have nothing else to do with it. Constipation is one harmless way for urobilinogen to increase in blood.
A urobilinogen in urine test measures the amount of urobilinogen in a urine sample. Urobilinogen is formed from the reduction of bilirubin. Bilirubin is a yellowish substance found in your liver that helps break down red blood cells. Normal urine contains some urobilinogen. If there is little or no urobilinogen in urine, it can mean your liver isn't working correctly.
Too much urobilinogen in urine can indicate a liver disease such as hepatitis or cirrhosis. A urobilinogen test may part of a urinalysis , a test that measures different cells, chemicals, and other substances in your urine. A urinalysis is often part of a routine exam. Your health care provider may have ordered this test as part of your regular checkup, to monitor an existing liver condition, or if you have symptoms of a liver disease.
These include:. Your health care provider will need to collect a sample of your urine. He or she will provide you with special instructions to ensure the sample is sterile. These instructions are often called as the "clean catch method.
You don't need any special preparations. If your health care provider has ordered other urine or blood tests, you may need to fast not eat or drink for several hours before the test. Your health care provider will let you know if there are any special instructions to follow. If your results are abnormal, it does not necessarily indicate you have a medical condition requiring treatment. Be sure to tell your health care provider about any medicines and supplements you are taking, as these can affect your results.
If you are a woman, you should tell your health care provider if you are menstruating. Learn more about laboratory tests, reference ranges, and understanding results.
This test is only one measure of liver function. If your health care provider thinks you might have a liver disease, additional urine and blood tests may be ordered. The medical information provided is for informational purposes only, and is not to be used as a substitute for professional medical advice, diagnosis or treatment.
Please contact your health care provider with questions you may have regarding medical conditions or the interpretation of test results. Urobilinogen in Urine. What is a urobilinogen in urine test? Other names: urine test; urine analysis; UA, chemical urinalysis.
What is it used for? Why do I need a urobilinogen in urine test? What happens during a urobilinogen in urine test? Clean your genital area with a cleansing pad given to you by your provider. Men should wipe the tip of their penis. Women should open their labia and clean from front to back.
Start to urinate into the toilet. Move the collection container under your urine stream. Collect at least an ounce or two of urine into the container, which should have markings to indicate the amounts.
Finish urinating into the toilet. Return the sample container as instructed by your health care provider. Will I need to do anything to prepare for the test? Are there any risks to the test? There is no known risk to having this test. What do the results mean? If your test results show too little or no urobilinogen in your urine, it may indicate: A blockage in the structures that carry bile from your liver A blockage in the blood flow of the liver A problem with liver function If your test results show a higher-than-normal level of urobilinogen, it may indicate: Hepatitis Cirrhosis Liver damage due to drugs Hemolytic anemia, a condition in which red blood cells are destroyed before they can be replaced.
This leaves the body without enough healthy red blood cells If your results are abnormal, it does not necessarily indicate you have a medical condition requiring treatment. Is there anything else I need to know about a urobilinogen in urine test? References Hinkle J, Cheever K. Bilirubin Serum ; p. Hinkle J, Cheever K. Fecal Urobilinogen; p. LabCE [Internet]. Lab CE; c— Clinical Significance of Urobilinogen in Urine; [cited Mar 1]; [about 2 screens].
American Association for Clinical Chemistry; c— Urinalysis: At a Glance; [updated May 26; cited Mar 1]; [about 2 screens]. Urinalysis: The Test; [updated May 26; cited Mar 1]; [about 4 screens]. Urinalysis; [cited Mar 1]; [about 2 screens].
Mayo Foundation for Medical Education and Research; c— Bilirubin test; Definition; Oct 13 [cited Mar 1]; [about 2 screens].
Liver disease: Symptoms; July 15 [cited Mar 1]; [about 3 screens]. Urinalysis: How you prepare; Oct 19 [cited Mar 1]; [about 4 screens]. Urinalysis: What you can expect; Oct 19 [cited Mar 1]; [about 5 screens]. Bethesda MD : U. Liver Function Tests and their Interpretation. Indian J Pediatr [Internet]. In the event of a medical emergency, call immediately.