Valacyclovir: 7 things you should know
Apr 01, · Valacyclovir is an antiviral drug. It slows the growth and spread of the herpes virus to help the body fight the infection. Valacyclovir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles (herpes zoster) in adults. Mar 02, · Valacyclovir is used to treat viral infections caused by a group of viruses called herpes simplex viruses. These infections include oral .
Drug information provided by: IBM Micromedex. Valacyclovir works best if it is used within 48 hours after the first symptoms of shingles or genital herpes e.
For recurrent outbreaks of genital herpes, valacyclovir works best if it is used within 24 hours after the symptoms begin to appear. If you are taking valacyclovir for the treatment of chickenpox, it is best to start taking valacyclovir as soon as possible after the first sign of ie chickenpox rash appears, usually within one day.
If you are using the oral suspension, use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid. Drink extra fluids so you will pass more urine while you are using this medicine.
This will keep your kidneys working well and what food is used as the base of guacamole prevent kidney problems. To help clear up your infection, keep taking valacyclovir for the full time of treatment, even if your symptoms begin to clear up after valafyclovir few days.
Do not miss any doses. Valacyclivir, do not use this medicine more often or for a longer time than your doctor ordered. The dose what is valacyclovir used for this medicine ks be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes valacycloivr the average qhat of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon how to make puffy bottle cap beads possible.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Mayo Clinic does not endorse companies or products.
Don't delay your care at Mayo Clinic Schedule your appointment now for safe in-person care. This content does not have an English version. This content does not have an Arabic version. See more conditions. Drugs and Supplements Valacyclovir Oral Route. Products and services. Free E-newsletter Subscribe to Housecall Our valcayclovir interest e-newsletter keeps you up to date on a wide variety of health topics. Sign up now. Proper Use Drug information provided by: IBM Micromedex Valacyclovir works best if it is used fro 48 hours after the first symptoms of shingles or genital herpes e.
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What is Valacyclovir?
May 18, · Valacyclovir is used to treat infections caused by certain types of viruses. In children, it is used to treat cold sores around the mouth (caused by herpes simplex) and chickenpox (caused by varicella zoster). In adults, it is used to treat shingles (caused by herpes zoster) and cold sores around the mouth. Jan 04, · Valacyclovir is a medicine used to treat or prevent genital herpes and shingles (herpes zoster) in adults. It’s also given to treat cold sores in adults and children who are at least 12 years old.4/5. Feb 24, · Valacyclovir is an antiviral medication that’s used to treat herpes outbreaks and cold sores. It’s sold under several brand names, the most common of which is Valtrex®. Valacyclovir is one of the most commonly used viral treatments.
Medically reviewed by Carmen Fookes, BPharm. Last updated on Feb 19, If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:. Note: In general, seniors or children, people with certain medical conditions such as liver or kidney problems, heart disease, diabetes, seizures or people who take other medications are more at risk of developing a wider range of side effects.
View complete list of side effects. Valacyclovir is an antiviral prodrug that is rapidly converted into acyclovir in the body. It should be started at the first sign of genital herpes or cold sore symptoms but is not a cure for these conditions. Valacyclovir only needs to be taken twice a day compared with acyclovir which needs to be taken five times a day.
Medicines that interact with valacyclovir may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with valacyclovir. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does.
Speak to your doctor about how drug interactions should be managed. Alcohol should be avoided while taking valacyclovir because it weakens the immune system and may exacerbate the side effects of valacyclovir. Note that this list is not all-inclusive and includes only common medications that may interact with valacyclovir. You should refer to the prescribing information for valacyclovir for a complete list of interactions. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use valacyclovir only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Patient Tips valacyclovir Print Save. How it works Valacyclovir is an antiviral prodrug that is rapidly converted into acyclovir inside the body.
These viruses cause illnesses such as cold sores, genital herpes, and shingles. Valacyclovir works in several different ways to prevent these viruses from replicating. Highly selective for thymidine kinase encoded by HSV and VZV viruses which converts acyclovir to acyclovir monophosphate, which is then converted to the diphosphate, then to the active triphosphate.
Also exhibits activity against other viruses that do not code for this enzyme. Valacyclovir belongs to the group of medicines known as antivirals. Upsides Valacyclovir is used to treat infections caused by herpes and varicella-zoster viruses, such as genital herpes, cold sores, shingles, and chickenpox. Approved to treat cold sores in children aged older than 12 and for the treatment of chickenpox in children aged two to 18 years.
Valacyclovir does not cure genital herpes or completely rid the body of herpes or varicella zoster virus. Valacyclovir is an oral tablet that only needs to be taken twice daily, compared to five times daily for acyclovir. This makes it more convenient for people to take. Treatment may last from one to 14 days depending on the condition being treated and the immunocompetency of the person being treated.
Treatment for cold sores should not exceed one day. May be taken with or without food. Valacyclovir is better absorbed than acyclovir. This results in concentrations in the body that are comparable to those achieved with IV acyclovir.
Does not appear to have any clinically significant drug-drug or drug-food interactions. Not metabolized by CYP enzymes. Generic valacyclovir is available. Downsides If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Headaches, nausea, vomiting, and abdominal pain are the most commonly reported side effects.
Rarely, may affect the kidneys or cause a bleeding disorder. In children aged less than 12, diarrhea, fever, dehydration, cold sores, and a runny nose are more commonly reported. May not be suitable for everybody, including people with advanced HIV, allogenic bone marrow transplant, kidney problems, taking certain medications, or in those who are dehydrated.
Elderly people may be more sensitive to some of the side effects of valacyclovir. Rarely, may cause side effects such as agitation, hallucinations, confusion, or seizures. The risk is higher in people with kidney disease and those receiving higher than the recommended dosage of valacyclovir. Valacyclovir is not a cure for genital herpes or herpes labialis cold sores. The dosage of valacyclovir needs reducing in people with kidney disease.
Adequate hydration must be maintained otherwise acyclovir can precipitate in the renal tubules if its solubility is exceeded in intratubular fluid. Weigh up the risks versus benefits of treatment because acyclovir the active form of valacyclovir crosses the placenta into the unborn child.
Acyclovir also passes into breastmilk. View complete list of side effects 4. Bottom Line Valacyclovir is an antiviral prodrug that is rapidly converted into acyclovir in the body. Tips Take valacyclovir exactly as directed by your doctor and for the exact time prescribed, even if your symptoms improve. Valacyclovir treatment is best started within 24 hours of symptom onset ie, rash, blisters, tingling, burning.
Data suggests valacyclovir is most effective if started within this time. Keep valacyclovir suspension in the refrigerator and shake well before use. Discard any unused portion after 28 days. Drink plenty of water while taking valacyclovir and do not allow yourself to become dehydrated. Although valacyclovir treats viruses, it is not effective against the flu or the common cold. If you have a shingles rash or a cold sore, try and keep it as clean and dry as possible.
Be careful not to transfer the virus to others; ensure you do not share linen, such as towels. Wearing loose clothing may help prevent a shingles rash from becoming irritated. If you are taking valacyclovir for genital herpes or cold sores avoid sexual contact until you have finished the course of treatment. At other times, always use a condom, because herpes can be transmitted in the absence of symptoms.
Seek urgent medical advice if you have any signs of an allergic reaction such as hives; difficulty breathing; facial or throat swelling. Herpes infections are highly contagious and you should cover your rash and avoid intimate contact. Also, avoid touching the rash and then your eyes. Wash your hands frequently. If you have treated yourself for genital herpes and it recurs, then seek retreatment as soon as possible.
If you have recurring cold sores, initiate treatment as soon as possible following the onset of symptoms tingling, burning, or itching. Talk to your doctor if you are pregnant or planning a pregnancy because acyclovir the active form of valacyclovir crosses the placenta into the unborn child.
Response and Effectiveness Valacyclovir is a prodrug that is rapidly converted to acyclovir after oral dosing. Peak concentrations of acyclovir are reached within one to three hours. It may take up to three days before a reduction in symptoms occurs.
Even if symptoms fully abate, valacyclovir should be taken until the prescribed course has been completed. Best started within hours of symptom onset. For recurrent episodes of genital herpes, therapy should be initiated within 24 hours of the onset of signs or symptoms; efficacy has not been proven if started after this time. Interactions Medicines that interact with valacyclovir may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with valacyclovir.
Common medications that may interact with valacyclovir include: cimetidine clopidogrel clozapine hepatitis B medications, such as entecavir some vaccinations, such as varicella virus or zoster virus vaccine NSAIDs, such as ibuprofen, diclofenac, or naproxen other antivirals, such as acyclovir probenecid tenofovir theophylline warfarin, an anticoagulant blood thinner zidovudine.
References Valacyclovir. Drug Status Availability Prescription only Rx. Reddy's Laboratories, Inc. Mylan Pharmaceuticals Inc. Roxane Laboratories, Inc. Drug Class. Purine nucleosides.